Meet the team

Principal Investigator


Alexandra-Chloé Villani, PhD

Alexandra-Chloé Villani, PhD

Director, Single-Cell Genomics Program, Center for Immunology and Inflammatory Diseases. Assistant Professor of Medicine, Harvard Medical School. Associate Scientist, Broad Institute of MIT and Harvard.

Postdoctoral Fellows


Leyre Zubiri, MD, PhD

Leyre Zubiri, MD, PhD

Postdoc, Oncologist

Dr. Leyre Zubiri is a medical oncologist specializing in patients receiving immunotherapy and suffering from secondary adverse events on the Severe Immunotherapy Complications service at MGH. Her PhD was focused on the liquid biopsy as a way to identify soluble tumor biomarkers in patients with malignant melanoma. She is actively engaged in the clinical and translational research effort in these patients to develop biomarkers to diagnose these toxicities earlier, allowing for appropriate management.

Daniel Zlotoff, MD, PhD

Daniel Zlotoff, MD, PhD

Postdoc, Cardiologist

Dr. Dan Zlotoff is a heart failure fellow and is interested in immune responses in the heart. He is currently studying the underlying mechanisms of immune checkpoint inhibitor-associated myocarditis.

Steven Blum, MD

Steven Blum, MD

Postdoc, Oncologist

Dr. Steve Blum is a medical oncology fellow who is interested in using systems immunology approaches to understand the relationship between the anti-tumor effects and toxicities that result from cancer immunotherapies.

Michelle Rengarajan, MD, PhD

Michelle Rengarajan, MD, PhD

Physician Investigator (Cl), Endocrinologist

Michelle is physician-scientist studying how epithelial and other stromal cells interface with infiltrating immune cells to preserve tissue function in organ-specific autoimmunity, using human thyroid autoimmunity as a model system.

Kamil Slowikowski, PhD

Kamil Slowikowski, PhD

Postdoc

Dr. Kamil Slowikowski is a computational biologist working on the analysis of single-cell transcriptomics studies with millions of cells from hundreds of patient samples.

Rachelly Normand, PhD

Rachelly Normand, PhD

Postdoc

Rachelly is a computational postdoc in the lab interested in studying autoimmune and infectious diseases by integrating multi-omic measurements at the single cell level. Specifically, Rachelly is working on studying immune-epithelial cell interactions in the thyroid gland in autoimmune and healthy patients. In addition, Rachelly leads the computational efforts to create a pan-disease blood cell atlas as part of the global Immune Cell Atlas project. This project will include a total of 15M cells in 30 different diseases and will serve as a comprehensive references for future PBMC studies.

Jacquelyn Nestor, MD, PhD

Jacquelyn Nestor, MD, PhD

Postdoc, Rheumatologist

Dr. Jacquelyn Nestor is a rheumatologist at Massachusetts General Hospital. As the experimental lead of the Immune Cell Atlas, she is interested in shared mechanisms of autoimmunity. She has also created a BioBank of patients with autoimmune diseases including Systemic Lupus Erythematosus (SLE), in order to better study the pathogenesis of SLE.

Christopher V. Cosgriff, MD, MPH

Christopher V. Cosgriff, MD, MPH

Postdoc, Pulmonary and Critical Care Fellow

Christopher is a pulmonary and critical care fellow interested in applying computational biology approaches to single-cell data to develop an understanding of the immunologic mechanisms underpinning immune checkpoint inhibitor (ICI) pneumonitis, as well as other forms of inflammatory lung injury. He also maintains an active interest in the application of machine learning to biomedical data across modalities to discover disease endotypes, inferences into heterogeneous treatment effects, and predictive models to support precision therapeutics.

Adrien Antoinette, PhD

Adrien Antoinette, PhD

Postdoc

Dr. Adrien Antoinette is a computational biologist utilizing single cell -omics approaches to study immune-related diseases. He is specially interested in systems approaches to understand cross-tissue and cross-disease pathological phenotypes.

Sergio Aguilar-Fernandez, PhD

Sergio Aguilar-Fernandez, PhD

Postdoc

Research Staff


Neal Smith, MSc

Neal Smith, MSc

Computational Scientist

Neal is a computational biologist utilizing single-cell -omics approaches to study the immune system in healthy and pathological states. Specifically, he is interested in understanding T cell mediated responses and how we can utilize TCR repertoire data to better understand T cell biology.

Courtney Ambrose, MSc

Courtney Ambrose, MSc

Senior Research Technician

Christopher Stueber, MSc

Christopher Stueber, MSc

Senior Research Technician

Isabela Kernin, MSc

Isabela Kernin, MSc

Computational Scientist

Roya Best

Roya Best

Research Associate

Wamia Said

Wamia Said

Associate Computational Biologist

Wamia is a recent graduate from University of Virginia.

Pragya Rawat, MSc

Pragya Rawat, MSc

Associate Computational Biologist

Pragya is interested in the intersection of genomics and systems biology, particularly in the analysis of gene expression patterns and regulatory networks to better understand complex biological systems. In the Villani Lab, she is contributing to the Blood Cell Atlas effort.

Elizabeth Tuttle

Elizabeth Tuttle

Research Associate

Alumni: Postdoctoral Fellows


Gary Reynolds, MBBS, PhD
Gary Reynolds, MBBS, PhD
Assistant Investigator, Rheumatologist

Faculty of Medicine at Harvard Medical School.

Mazen Nasrallah, MD, MSc
Mazen Nasrallah, MD, MSc
Postdoc
Molly Fisher Thomas, MD, PhD
Molly Fisher Thomas, MD, PhD
Postdoc, Gastroenterologist
Pritha Sen, MD
Pritha Sen, MD
Infectious Disease Specialist

Instructor in Medicine at Brigham and Women’s Hospital.

Tariq Daouda, PhD
Tariq Daouda, PhD
Postdoc

Alumni: Research Staff


Alice Tirard
Alice Tirard
Research Associate

Scientific Communications Specialist at Dyno Therapeutics.

Aonkon Dey
Aonkon Dey
Associate Computational Biologist

PhD candidate (Immunology) at Icahn School of Medicine at Mount Sinai.

Elizabeth Byrne, MSc
Elizabeth Byrne, MSc
PhD Student
Hoang Tran
Hoang Tran
Associate Computational Biologist

PhD candidate (Biomedical Sciences) at UMass Chan Medical School.

Jessica Tantivit, BSc
Jessica Tantivit, BSc
Research Associate

MD candidate at UC San Diego School of Medicine.

John McGuire
John McGuire
Research Associate
Juliet Bramante
Juliet Bramante
Research Associate
Kasidet Manakongtreecheep, BSc
Kasidet Manakongtreecheep, BSc
Research Associate

PhD candidate (Biological and Biomedical Sciences) at Harvard Medical School.

Nandini Samanta
Nandini Samanta
Research Associate

PhD candidate (Biomedical Sciences and Neuroscience) at Icahn School of Medicine at Mount Sinai.

Sidney Martin
Sidney Martin
Research Associate

PhD candidate (Cancer Biology) and Fontaine Fellow at University of Pennsylvania.

Swetha Ramesh
Swetha Ramesh
Computational Scientist

PhD candidate at UCLA.

Tos Chan
Tos Chan
Computational Scientist
Yash Sonthalia, MSE
Yash Sonthalia, MSE
Computational Biologist