Principal Investigator
Alexandra-Chloé Villani, PhD
Director, Single-Cell Genomics Program, Center for Immunology and Inflammatory Diseases. Assistant Professor of Medicine, Harvard Medical School. Associate Scientist, Broad Institute of MIT and Harvard.
Postdoctoral Fellows
Leyre Zubiri, MD, PhD
Dr. Leyre Zubiri is a medical oncologist specializing in patients receiving immunotherapy and suffering from secondary adverse events on the Severe Immunotherapy Complications service at MGH. Her PhD was focused on the liquid biopsy as a way to identify soluble tumor biomarkers in patients with malignant melanoma. She is actively engaged in the clinical and translational research effort in these patients to develop biomarkers to diagnose these toxicities earlier, allowing for appropriate management.
Daniel Zlotoff, MD, PhD
Dr. Dan Zlotoff is a heart failure fellow and is interested in immune responses in the heart. He is currently studying the underlying mechanisms of immune checkpoint inhibitor-associated myocarditis.
Steven Blum, MD
Dr. Steve Blum is a medical oncology fellow who is interested in using systems immunology approaches to understand the relationship between the anti-tumor effects and toxicities that result from cancer immunotherapies.
Michelle Rengarajan, MD, PhD
Michelle is physician-scientist studying how epithelial and other stromal cells interface with infiltrating immune cells to preserve tissue function in organ-specific autoimmunity, using human thyroid autoimmunity as a model system.
Rachelly Normand, PhD
Rachelly is a computational postdoc in the lab interested in studying autoimmune and infectious diseases by integrating multi-omic measurements at the single cell level. Specifically, Rachelly is working on studying immune-epithelial cell interactions in the thyroid gland in autoimmune and healthy patients. In addition, Rachelly leads the computational efforts to create a pan-disease blood cell atlas as part of the global Immune Cell Atlas project. This project will include a total of 15M cells in 30 different diseases and will serve as a comprehensive references for future PBMC studies.
Jacquelyn Nestor, MD, PhD
Dr. Jacquelyn Nestor is a rheumatologist at Massachusetts General Hospital. As the experimental lead of the Immune Cell Atlas, she is interested in shared mechanisms of autoimmunity. She has also created a BioBank of patients with autoimmune diseases including Systemic Lupus Erythematosus (SLE), in order to better study the pathogenesis of SLE.
Christopher V. Cosgriff, MD, MPH
Christopher is a pulmonary and critical care fellow interested in applying computational biology approaches to single-cell data to develop an understanding of the immunologic mechanisms underpinning immune checkpoint inhibitor (ICI) pneumonitis, as well as other forms of inflammatory lung injury. He also maintains an active interest in the application of machine learning to biomedical data across modalities to discover disease endotypes, inferences into heterogeneous treatment effects, and predictive models to support precision therapeutics.
Adrien Antoinette, PhD
Dr. Adrien Antoinette is a computational biologist utilizing single cell -omics approaches to study immune-related diseases. He is specially interested in systems approaches to understand cross-tissue and cross-disease pathological phenotypes.
Research Staff
Neal Smith, MSc
Neal is a computational biologist utilizing single-cell -omics approaches to study the immune system in healthy and pathological states. Specifically, he is interested in understanding T cell mediated responses and how we can utilize TCR repertoire data to better understand T cell biology.
Swetha Ramesh
Swetha is a computational biologist who develops and utilizes computational approaches to analyze single-cell -omics datasets. Specifically, she focuses on the ICI-related myocarditis efforts and other collaborative projects.
Aonkon Dey
Aonkon is interested in developing solutions for single-cell genomics that leverage a comprehensive knowledge of biology, mathematics and computer science. Currently engaged in using single-cell multi-omics to derive cellular biomarkers and gene signatures for immunotherapy response, immune-related adverse events, and developing in-silico strategies for finding new CAR T therapies for solid tumors.
Wamia Said
Wamia is a recent graduate from University of Virginia.
Pragya Rawat, MSc
Pragya is interested in the intersection of genomics and systems biology, particularly in the analysis of gene expression patterns and regulatory networks to better understand complex biological systems. In the Villani Lab, she is contributing to the Blood Cell Atlas effort.
Alumni: Postdoctoral Fellows
Mazen Nasrallah, MD, MSc
Pritha Sen, MD
Instructor in Medicine, Brigham and Women’s Hospital
Gary Reynolds, MBBS, PhD
Member of the Faculty of Medicine, Harvard Medical School. Gary is a Rheumatologist Clinician Scientist with an interest in applying genomics and systems biology approaches to immune-mediated rheumatic diseases with a particular interest in Giant Cell Arteritis.
Alumni: Research Staff
Jessica Tantivit, BSc
Jessica Tantivit is currently a MD candidate at UC San Diego School of Medicine.
Kasidet Manakongtreecheep, BSc
Kasidet Manakongtreecheep is currently a PhD candidate (Biological and Biomedical Sciences) at Harvard Medical School
Alice Tirard
Alice is a currently a Scientific Communications Specialist at Dyno Therapeutics
John McGuire
Juliet Bramante
Hoang Tran
Hoang Tran is currently a PhD candidate (Biomedical Sciences) at UMass Chan Medical School
Nandini Samanta
Nandini Samanta is currently a PhD candidate (Biomedical Sciences and Neuroscience) at the Icahn School of Medicine at Mount Sinai.
Sidney Martin
Sidney Martin is currently a PhD candidate (Cancer Biology) and Fontaine Fellow at the University of Pennsylvania School of Medicine.