We are developing and implementing single-cell 'omics' strategies and systems immunology approaches to understand the players and rules governing human immune response regulation as a foundation for deciphering human traits and diseases.
The Villani laboratory seeks to establish a comprehensive roadmap of the human immune system by achieving a higher resolution definition and functional characterization of cell subsets and rules governing immune response regulation, as a foundation to decipher how immunity is dysregulated in diseases.
To study and model the immune system as a function of “healthy” and inflammatory states, disease progression, and response to treatment, we use:
Our multi-disciplinary team of immunologists, geneticists, computational biologists, and physicians work towards answering several key questions:
Collectively, our groundwork is paving the way for developing a human immune lexicon that is key to promoting effective bench-to-beside translation of findings.