We are developing and implementing single-cell 'omics' strategies and systems immunology approaches to understand the players and rules governing human immune response regulation as a foundation for deciphering human traits and diseases.
The Villani Laboratory seeks to establish a comprehensive roadmap of the human immune system by achieving a higher resolution definition and functional characterization of cell subsets and rules governing immune response regulation, as a foundation to decipher how immunity is dysregulated in diseases.
To study and model the immune system as a function of “healthy” and inflammatory states, disease progression, and response to treatment, we use:
Our multi-disciplinary team of immunologists, geneticists, computational biologists, and physicians work towards answering several key questions:
Collectively, our groundwork is paving the way for developing a human immune lexicon that is key to promoting effective bench-to-beside translation of findings.
February 5, 2024 | Melanoma Immunotherapies & Immune-related Adverse Events: A Conversation with Dr. Alexandra-Chloé Villani |
June 29, 2023 | Immune Cartographers: The Scientists Mapping the Immune Cell Atlas |
August 31, 2022 | Researchers take aim at cancer drugs’ toxic side effects |
June 14, 2021 | Safer Immunotherapy |
April 29, 2021 | COVID-19 Autopsies Uncover Ways The Coronavirus Kills |
March 26, 2019 | The Search for Immunotherapy Success |