Our Mission

The Villani Laboratory seeks to establish a comprehensive roadmap of the human immune system—achieving higher resolution definitions of cell subsets and the rules governing immune response regulation.

Our Approach

• Systems immunology approaches
• Cutting-edge immunogenomics
• Single-cell multi-omics strategies
• Integrative computational frameworks

Key Questions We're Exploring

• Do we know all existing blood immune cell subsets?
• How do circulating immune cells mirror those in tissue microenvironments?
• Can we improve immunotherapy efficacy by increasing specificity?

Our Team

A multi-disciplinary group of immunologists, geneticists, computational biologists, and physicians working to develop a human immune lexicon for bench-to-bedside translation.